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Along these lines, recent findings from our laboratory demonstrated that, in addition to arachidonic acid, the omega-3 poly-unsaturated fatty acids (found in fish oil), namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can also interact with aspirin-acetylated COX-2 to generate bioactive compounds, namely resolvins (Serhan et al., 2004)